MEMS Project Seminar Pigment epithelium-derived factor, a neurotrophic and antiangiogenic factor for the retina: structure-function studies Patricia Becerra National Eye Institute Monday, March 24, 2003 11:00 AM Technology Building Room A362 This seminar is hosted by Michael Gaitan (EEEL)

Abstract

The research interests of my laboratory are in the area of protein structure as it relates to function, with a focus on the interactions of components involved in cell differentiation and survival. Our research at NEI has applied these interests to systems in the retina.

My lab group has been studying pigment epithelium-derived factor (PEDF), a protein that acts in neuronal differentiation and survival in cells derived from the retina and CNS. PEDF inhibits angiogenesis and its expression is down-regulated over the replicative lifespan of mammals. This interesting factor is secreted by retinal pigment epithelial cells into the interphotoreceptor matrix, where it acts on photoreceptor cells. Its importance in the development, maintenance, and function of the retina and CNS is evident in animal models for inherited and light-induced retinal degeneration, as well as for degeneration of spinal cord motor neurons.

I will discuss the structure, biology and mechanisms of action of PEDF.